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The 3-month on, 2-month off structure preserves that sensitivity and allows natural GH secretion rhythms to reassert themselves during the rest phase

OXPHOS, oxidative phosphorylation

References Deumer US, Varesi A, Floris V, et al

Patients with favorable GLP1R rs6923761 variants may experience faster satiety at lower doses, while FTO rs9939609 risk carriers might benefit from higher therapeutic targets

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The clinical importance of GLP-1 has been highlighted by the development of GLP-1 receptor agonists (such as semaglutide and liraglutide) for managing type 2 diabetes and, under specific NICE criteria, for weight management