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Merritt JA, Clayman G, Swisher SG , Nemunaitis J, El-Naggar A, Timmons T, Laurence D, Kemp B, Frederick M, Connors D, Bruso P, Geopfert H, Hong WK, Roth JA

The Gla domain is responsible for high-affinity binding of calcium ions (Ca 2+ ) to Gla proteins, which is often necessary for their conformation, and always necessary for their function

Endocr Rev 20(5):649688 Dias V, Junn E, Mouradian MM (2013) The role of oxidative stress in Parkinsons disease

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ACE (Angiotensin-converting enzyme) is increased in RA-FLS that catalyses the formation of angiotensin II from its inactive precursor, angiotensin I, and then raises the angiotensin II concentration in RA patients that leads to synovial hypoxia by hypoxia-inducible factor (HIF-1) 64

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