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It mediates weight-reducing effects in the brain and increases plasma levels of soluble leptin receptor (sOb-R) in newly diagnosed individuals with type 2 diabetes mellitus (T2DM) (108)

Consensus statement by the American Association of Clinical Endocrinologists and American College of Endocrinology on the comprehensive type 2 diabetes management algorithm - 2020 executive summary

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The inhibition of CMPK2 expression following FTO reduction led to decreased mtDNA production and cGAS-STING signaling activation, thereby suppressing inflammatory cytokine expression and ameliorating arthritis (61)

doi:10.1210/jc.2010-2879 Simpson T, Kure C, Stough C