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Briefly, 5-day-old Arabidopsis root tips were excised and rapidly frozen using a high-pressure freezing apparatus (EM ICE, Leica)

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Weight of evidence: Overall evidence is Low-Moderate: multiple animal studies and a growing number of small clinical trials suggest benefits across gutbrain signaling, social and behavioral domains, gastrointestinal symptoms, and neurophysiological patterns, yet most human studies rely on caregiver-reported outcomes, lack biomarker integration, and seldom control for diet, comorbidities, or baseline microbiome composition

Mhler, 2012)

It is used in the treatment of melasma and hyperpigmentation of the skin