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Acta Neurol

A recent study introduces a peptide PROTAC specifically designed to target and degrade the cysteine-histidine-rich 1 (CH1) domain of p300, a vital co-activator involved in oncogenic signaling pathways, particularly in PCa (Zhang et al., 2024)

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The complex binds copper through the N-terminal amine, the imidazole nitrogen of histidine, and the deprotonated amide nitrogen of the Gly-His peptide bond, forming a stable square-planar coordination geometry