doi: 10.1128/jb.00969-07 18 ChengY.ChengH.JiangC.QiuX.WangK.HuanW.et al
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The enzyme involved in glutamine synthesis, GS, is also involved in tumor biology
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Quercetin is best known for its antioxidant activity in scavenging free radicals
Introduction Pancreatic ductal adenocarcinoma (PDAC) originates from the exocrine cells of the pancreas and accounts for 90% of all pancreatic cancers ( KRAS , found in 90% of cases, along with loss of function mutations in TP53 , SMAD4 and CDKN2A ( PDAC has a 5-year survival rate of 13% ( There has been a shift in focus to direct cancer surveillance to high-risk subgroups ( With global PDAC incidence rising alongside diabetes prevalence in 2079-year-old individuals from 2025 to 2050, it prompts the question as to how many new PDAC cases are linked to diabetes ( Figure 1A ) ( Figure 1B )
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