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International journal of molecular sciences , 26 (6), 2691

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Front Neurosci 16:851394 Chuang Y-C, Chen S-D, Lin T-K et al (2010) Transcriptional upregulation of nitric oxide synthase II by nuclear factor-kappaB promotes apoptotic neuronal cell death in the hippocampus following experimental status epilepticus [J]

[iv] Challenges Associated With FIH Trials Since these studies represent the first administration of an investigational drug in humans, they are associated with inherent challenges, especially safety