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Why Constipation Happens on GLP-1 Constipation on GLP-1 is rarely caused by one factor alone

Clinical trials have shown that semaglutide and liraglutide are generally well tolerated, with gastrointestinal disorders being the most commonly reported AEs, including nausea, diarrhea, vomiting, and constipation, leading to dose reduction or temporary treatment interruption in 12.5% of study participants [40,41,42]

Most available evidence comes from in vitro and pre-clinical studies

[12] Aging in both sexes is accompanied by profound decreases in GH output and in plasma IGF-I concentrations

Notably, leptin may serve as a crucial biological signal for GLP-1, working in synergy, to decrease food intake and body weight

02/16/2026 Electronic publication Footnotes Conflict of interest: TF has served on advisory boards for Peptron, Abbvie, Eli Lilly, Bluerock, Bayer, and Bial