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Glutathione is known as the body's master antioxidant, both for its antioxidant properties and its role in regenerating other antioxidants
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Bcl-2 is overexpressed in docetaxel-resistant cells, thereby counteracting docetaxel-induced apoptosis [203,205,206]
Notably, Through a feedback mechanism, mTORC1 inhibition may momentarily increase mTORC2 signaling, causing temporary metabolic disruptions during the first phase of treatment (224), which can transiently disrupt metabolism and frequently leads to hyperlipidemia, necessitating concomitant lipid-lowering therapy (237239)
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