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demonstrated that hypericin-mediated PDT (HY-PDT) induces ferroptosis in CCA cells by inhibiting the AKT/mTORC1/GPX4 axis, downregulating GPX4, decreasing GSH, and increasing ROS and lipid peroxidation products, while also suppressing proliferation, migration, and EMT

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Most countries in Southeast Asia experience frequent and cyclical epidemics of dengue throughout the year