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Elevated glutamate levels in the basal ganglia, an area of the brain devoted to motor control, motivation, and decision making, was found to be associated with depressed patients who also have systemic inflammation (Neuroscience Online)
H M, Dziedzic K, Grecka D, Jdrusek-Goliska A, Gujska E
Hormonal factors
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Buprenorphine comes in a number of different formulations: Sublingual or Buccal Buprenorphine (Subutex) or Buprenorphine-Naloxone (Suboxone, Zubsolv)
But interestingly, the researchers did see a statistically significant response in the non-motor symptoms: The liraglutide treated group experienced improvements in measures of non-motor symptoms, activities of daily living and quality of life, while the placebo group did not
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