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Placebo: -2.1%

Tirzepatide While both medications work similarly, tirzepatide also mimics another hormone in your body called the gastric-inhibitory polypeptide (GIP), which further stabilizes your blood sugar and reduces hunger

Prompt medical care usually prevents lasting effects

N Engl J Med 2025;Mar 29:[Epub ahead of print].

Those with cardiovascular concerns, blood pressure issues, or taking erectile dysfunction medications or nitrates may be sensitive to ingredients that may affect blood flow

Some online retailers offer their own clinician to approve the drug's use, but a recent study found that 92% of GLP-1 websites prescribed the medication with little to no oversight, and many did not screen patients for potential allergies or other conditions that would prevent use