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The evidence base is still preliminary but promising. A big 2025 review looked at 68 different studies on LDN and found some pretty impressive results

The drug has been around since 2013 and originally was created for consumers with diabetes

Inhibiting mTOR signaling in CAR T cells alters immunometabolism and enhances function Intrigued by our pre- and post-infusion results suggesting a significant role for mTOR activity on the efficacy of CAR T cells of LTR, we asked whether we could harness the mTOR pathway to enhance antitumor activity of CAR T cells of STR

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Diarrhea is another commonly reported gastrointestinal side effect that may range from mild loose stools to more significant episodes that could lead to fluid and electrolyte imbalances if severe or prolonged