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While many patients can reach their weight-loss goals within six months to a year, others need up to two years, and some require long-term GLP-1 maintenance due to the chronic nature of their condition

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1,2 The most potent stimuli for glucagon secretion are hypoglycemia, prolonged fasting, exercise, and after a protein-rich meal

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All protocols require a prescription and physician oversight

Other important risk factors include: Irregular meal patterns or missed meals : Since GLP-1 receptor agonists affect appetite and gastric emptying, skipping meals whilst taking other diabetes medications can precipitate hypoglycaemia Increased physical activity : Unplanned or vigorous exercise increases glucose utilisation and may require medication adjustments Renal impairment : The impact varies by drug