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696 Fer-1 can also reduce the accumulation of iron and ROS, downregulate the ferroptosis-related genes PTGS2 and their products, thereby inhibiting the ferroptosis of oligodendrocytes, and finally alleviating the white matter injury after SCI in rats and promoting functional recovery

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Thus, the formulations or compositions described herein are useful in surgical procedures including, by way of non-limiting examples, cochleostomy, labyrinthotomy, mastoidectomy, stapedectomy, endolymphatic sacculotomy or the like

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, cellular communication), which over a chronic period might induce neurodegeneration and cognitive deficits [90,91,92]