While glucagon-like peptide-1 (GLP-1) receptor agonists like semaglutide and tirzepatide (a dual GIP/GLP-1 agonist) have revolutionized care, the pipeline is advancing toward novel mechanisms offering potential for enhanced efficacy, tolerability, and convenience
Injectable GLP-1s like Zepbound produce slightly higher weight reduction in head-to-head trials, but many people discontinue weekly injections because the routine becomes burdensome
Fiber supplements: Adequate fiber intake promotes regular gastric motility and can help food move through the system more efficiently, even with tirzepatide-induced slowing
There is a boxed warning regarding thyroid C-cell tumors based on rodent studies, with a contraindication in patients with personal or family history of MTC or MEN2
Transforming growth factor- signaling: from tumor microenvironment to anticancer therapy
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