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The abovementioned product was verified by FDA through postmarketing surveillance and shows no valid Certificate of Product Notification (CPN) as of 23 November 2022

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10.1016/j.actbio.2017.12.043 [DOI] [PMC free article] [PubMed] [Google Scholar] Zhang C., Xie Y., Chen H., Lv L., Yao J., Zhang M., et al

So a compound that looks clean in rat intestinal epithelium can still provoke a response in human tissue

Patients with mild disease are treated with topical regimens, including retinoids, benzyl peroxide, and/or antibiotics, and systemic treatments are added for patients with moderate to severe acne [1, 4]