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GHK-Cu 1 The activity of GHK-Cu is thought to be multifaceted and includes: GHK-Cu has been associated with the upregulation of genes involved in tissue repair, anti-inflammatory signaling, and antioxidant defense, and the downregulation of genes linked to fibrosis and oxidative stress

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Inhibition of PGC-1 expression has been shown to result in decreased expression of the mitochondrial fusion protein Mfn2, increased expression of p-Drp1, and increased mitochondrial fragmentation (Wang et al., 2019d)