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Senolytic FOXO4-DRI can inhibit FOXO4 binding by disrupting the p53-FOXO4 interaction and selectively cause apoptosis via p53 nuclear exclusion in senescent cells and aging mouse models, which may be a promising approach for preventing senescence 11

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Glutathione helps improve skin health by reducing oxidative stress and inhibiting melanin production

Based on this inspiration, we propose a strategy to effectively amplify PDT by depleting endogenous GSH, and generate active molecules that are more lethal to biofilms by utilizing endogenous GSH, thus facilitating the eradication of biofilms

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