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Peroxisome proliferator-activated receptor gamma coactivator 1 in caloric restriction and other models of longevity

In Vitro Pantethine (10-1000 M) inhibits cholesterol production in mouse liver slices [1]

SIRT1 activation restores autophagy by deacetylating FOXO3a and upregulating autophagy-related genes, including Atg5 and LC3-II, enhancing cellular stress adaptability and improving insulin sensitivity

Some researchers also suggest it may interact with neurons via the Mitogen-Activated Protein Kinase (MAPK) pathway, which regulates intercellular signaling [15]

Sanders et al., 1999)

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