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That curiosity is valid

The SURPASS clinical trial program, which evaluated tirzepatide for type 2 diabetes over periods extending to 52 weeks and beyond, demonstrated sustained glycemic improvements without evidence of significant tachyphylaxis (rapid tolerance development) for the primary glucose-lowering effects

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For example, interference with CYP2D6 activity may influence tamoxifen bioactivation, potentially affecting therapeutic efficacy

In obesity care, they represent a rapidly expanding therapeutic frontier, centered on weight reduction, metabolic health, and patient-driven demand