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This is highly significant, as it reveals that rare mutations in the HRD motifs of protein kinases are highly penetrant and disease-causing, which provides a strong functional rationale for the R311C mutation in the HRD motif of CaMKK2 being considered a potential monogenic model of bipolar 1 disorder

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Furthermore, our extensive treatments promote hormonal equilibrium, including hormone replacement options and thyroid health services, which are vital for many women experiencing hormonal changes

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The inclusion criteria were: healthy males and females between the ages 5570 years