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SURMOUNT-5 was a 72-week, open-label, Phase 3b randomised trial of 751 adults with obesity but without diabetes, comparing maximum-tolerated tirzepatide (10 or 15 mg) against maximum-tolerated semaglutide (1.7 or 2.4 mg)

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(2011) 6:e20470

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doi: 10.1038/s42003-022-04028-x

[221] [222] The full profile of amphetamine's short-term drug effects in humans is mostly derived through increased cellular communication or neurotransmission of dopamine, [37] serotonin, [37] norepinephrine, [37] epinephrine, [190] histamine, [190] CART peptides, [20] [216] endogenous opioids, [223] [224] [225] adrenocorticotropic hormone, [226] [227] corticosteroids, [226] [227] and glutamate, [195] [212] which it affects through interactions with CART, 5-HT 1A , EAAT3, TAAR1, VMAT1, VMAT2, and possibly other biological targets