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These prespecified analyses considered factors such as age, hypertension, heart failure, eGFR, proteinuria, new users after the index day, enrollee after 2006 and concurrent usage of other medications for glycemic control, and renin-angiotensin-aldosterone system (RAAS) blockers

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This evolution is often accompanied by low-grade inflammation, T cell exhaustion, myeloid dysfunction, and metabolic stress, ultimately leading to a decline in antitumor immunity and reduced efficacy of immunotherapy

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