In addition to inhibiting NF-kB signaling, riboflavin can also inhibit critical components of the non-canonical inflammasomes, such as caspase-1 activity 47 , either via the AIM2 cytosolic innate immune receptor, which recognizes double-stranded DNA (dsDNA) released during cellular perturbation, or via the Nod-like receptor NLRC4, which recognizes bacterial ligands such as flagellin and the type three secretion system (T3SS) 47
96 Increased serum levels of GH and IGF1 have been observed in type 2 diabetes mellitus (T2D) patients with proliferative diabetic retinopathy compared to T2D patients with nonproliferative retinopathy or with no evidence of this complication
Abbreviations: ALD, alcoholic liver disease
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Ecotoxicology 27, 10691086
