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GLP-1 may induce sodium excretion by blocking sodium reabsorption in the proximal tubule through inhibition of sodium-hydrogen exchanger isoform 3 (NHE3) activity [23], as no GLP-1 receptors appear to be present in human kidneys outside of the renal vasculature [19]

It is essential that any decision to use both medicines is made with full clinical oversight, as each patient's circumstances differ significantly

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The legality of peptides varies by country and jurisdiction, and it is important to consult with local regulations before purchasing or using peptides

Nat Rev Urol 9 , 678690 (2012)