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Their use may be evaluated through physical testing, dissolution studies, and stability observations
PT2385 binds to the PAS-B domain of HIF-2, a region crucial for heterodimerization with HIF-1 (ARNT), effectively preventing DNA binding and transcriptional activation of downstream oncogenic targets such as VEGF, cyclin D1, and GLUT1 (187)
Allingbjerg, M.-L., Hansen, S
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