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[DOI] [PMC free article] [PubMed] [Google Scholar] 67.Shelton MD, Chock PB, Mieyal JJ

Because of the high heterogeneity of tumors, according to Darwinian evolutionary principles, drug-resistant mutants are selected, or subpopulations of primary resistant tumor stem cells in the dormant phase can cause tumors to regrow or spread

doi: 10.1016/j.bbrc.2008.01.030 110 MaJYuanHZhangJSunXYiLLiWet al

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Current Pharmaceutical Design : Studies focus on its regenerative properties linked to actin upregulation, facilitating faster healing of injuries