Hepatocellular injury, meaning damage to liver cells, releases stored vitamin B12 into the blood, and chronic liver disease reduces the clearance that normally keeps levels in check
Clinical depth vs simplicity
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Cannabis has complex gastrointestinal effectswhilst some patients use it to manage nausea, chronic heavy use is associated with cannabinoid hyperemesis syndrome (CHS) , characterised by severe cyclical vomiting
In some cases, insurers enforce step-therapy rules, meaning you may need to try less expensive medications before theyll approve GLP-1 treatment
Br J Dermatol 174:165-168