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25 The first line includes superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx), which encompass cytosolic SOD1 and mitochondrial matrix SOD2 that remove O 2 , catalases, and GPxs that eliminate H 2 O 2 , and certain GPxs and PRDXs that reduce lipid peroxides

When this gene has a common variation, that enzyme works less efficiently

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