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You should not use GLP-1 medications if you have: Personal or family history of medullary thyroid cancer Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Previous severe allergic reaction to semaglutide or liraglutide Current pregnancy or planning to become pregnant History of pancreatitis (requires careful evaluation) Severe gastrointestinal disease Additionally, these medications are not typically recommended for patients under 18 years old, though Saxenda has some pediatric approval for adolescents 12 and older with obesity

These drugs work by mimicking the effect of a hormone called glucagon-like peptide-1 (GLP-1), which helps control blood sugar levels and promotes weight loss

Occurrence of nausea, vomiting and diarrhoea reported as adverse events in clinical trials studying glucagon-like peptide-1 receptor agonists: A sys- tematic analysis of published clinical trials

Despite these differences, elimination timelines are relatively consistent

Thank you THL

2020;23(Suppl 1):S116