does semaglutide make you poop a lot Ozempic Side Effects — Everything Need to Know Why Does Semaglutide Cause Diarrhea?

[1] Rotate injection sites systematically

JAMA, 330 (18), 1795-1797

This class of compounds binds to key receptors in the brain, pancreas, and gastrointestinal (GI) tract, instigating several biological reactions: Enhances insulin secretion Slows gastric emptying Increases -cell proliferation Reduces glucagon release Mitigates hunger signaling These actions combine to regulate appetite, food intake, and the physical feeling of fullness (satiety)

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The body starts adapting to the higher GLP-1 levels

For some patients, this disruption manifests as diarrhea, while others may experience alternating constipation