Kaiya et al., 2003
Figure 5A,B confirm a stable photoluminescence of PLGA nanoparticles encapsulating DDA-GSH-AuNCs in PBS or DMEM (Dulbeccos Modified Eagle Medium) contains 10% FBS (fetal bovine serum) for 24 hours with comparable photoluminescence stability in water as a control
Understanding and addressing irAEs is a pressing issue for another reason as well: given that only about a third of cancer patients respond to immune checkpoint inhibitors, research labs and pharmaceutical companies are doubling down on efforts to expand the efficacy to more patients, and one of the approaches is to combine different immunotherapeutics to target different pathways
RNA-sequencing Total RNA was extracted using Qiazol (Qiagen, Hilden, Germany), purified from DNA contamination through a DNase I (Qiagen) digestion step, and further enriched by Qiagen miRNeasy columns profiling (Qiagen)
Or it might not do anything
2023, SolaLeyva, Alberto, et al