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*Correspondence: Wei Zhang, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

doi: 10.1074/jbc.RA119.010950 20 ZhuJChenYChenHSunYYanLZhuMet al

Spontaneous Erections (Male Subjects): Due to the potent MC4R activity, male subjects may experience unexpected and prolonged erections during the initial research phase