In STEP 1, participants without diabetes who received 2.4mg of semaglutide weekly lost an average of 14.9% of their body weight over 68 weeks
She has no significant past medical history or comorbidities
Tirzepatide's dual-action approach Tirzepatide (found in Mounjaro and Zepbound) works differently by activating not one, but two hormone receptors: GLP-1 receptors (the same ones that semaglutide targets) GIP (glucose-dependent insulinotropic polypeptide) receptors This dual-action approach creates complementary effects on hunger, metabolism, and blood sugar regulation and yielding more impactful results than GLP-1 alone
Longer duration was also linked to increased occurrences of major adverse cardiovascular events (MACE), expanded MACE, and nephropathy events
Garvey WT, Frias JP, Jastreboff AM, le Roux CW, Sattar N, Aizenberg D, et al
Problems: Not subject to US safety regulations Products not FDA-approved for US market Counterfeit medications common Customs may seize shipments No legal recourse if product causes harm Improper storage during international shipping May violate US import laws Common Countries: India China Mexico Canada (some legitimate but many questionable) Various Caribbean nations Even if some overseas pharmacies are legitimate in their countries, importing prescription medications for personal use occupies a legal gray area and lacks safety oversight
