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In addition, these drugs are currently utilized in patients with Alzheimers disease for the treatment of aggression, suggesting a psychometabolic role (116)
However, controversy still exists as to whether it is best to therapeutically promote or inhibit GIP action for beneficial effects on glycemic control and body weight [[929], [930], [931]] as both GIPR agonists [932] and antagonists [933,934] have decreased body weight in preclinical studies as individual treatments, but also to induce synergistic body weight loss when combined with GLP-1R agonists
