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Waters Corporation, Milford, MA, USA) coupled to an Exactive Plus Orbitrap mass spectrometer (Thermo Fisher

The resuspended cells can be homogenized under chilled conditions and centrifuged (Sorvall, Thermofisher)

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In separate randomized clinical studies, average weight loss reached up to 22.5% with Zepbound injection, 20.7% with Wegovy HD injection, 16.6% with oral Wegovy and 11.1% with oral Foundayo

The inclusion body preparation involves resuspending of cell pellet in non-denaturing lysis buffer (Tris-HCl + Urea) by stirring and treating with lysozyme at room temperature

Formulated by a compounding pharmacy