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Monitoring and Precautions Vigilance: Monitoring for therapeutic escape, where a patient may eventually need a dose titration or the addition of another agent due to the progressive nature of the disease

The conversion of oxygen (O 2 ) into cellular energy involves its reduction to H 2 O by accepting 4 electrons

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Final approval of the manuscript: H.S.K., T.Y., C.H.J., J.Y.P., W.J.L