Conceptual Origin: From Empirical Observation to Theoretical Framework In the 16th century, the Swiss physician Paracelsus established the philosophical foundation for dose-response relationships with his statement, The dose makes the poison ( Sola dosis facit venenum )
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Introduction Sulfur is an essential element that is incorporated into various cellular metabolites and used for multiple metabolic processes in fungi, including the proteogenic amino acids cysteine (Cys) and methionine (Met), oxidative stress defense [glutathione (GSH) and ergothioneine (EGT)], methylation [ S -adenosylmethionine (SAM)], epipolythiodioxopiperazine (ETP) toxin biosynthesis (e.g., gliotoxin) and iron metabolism (FeS clusters) (Struck et al., 2012
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Theoretically, the proinflammatory cytokines secreted by activated KCs after ethanol exposure could induce hepcidin expression via activating the JAK/STAT3 pathway [46]
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