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The methionine cycle consists of 4 substances: Methionine S-adenosylmethionine (SAM) S-adenosyl homocysteine (SAH) Homocysteine The essential task of this cycle is to break down harmful homocysteine and to regenerate it again into the methyl donor S-adenosylmethionine (SAM)

Some individuals carry genetic variations that reduce conversion efficiency

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Most research protocols involve a consistent, measured application over a period of several weeks, often 8 to 12 weeks, to allow the compound to exert its full metabolic influence

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