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FDA approved the first GLP-1 RA as adjunctive therapy to improve glycemic control in patients with type 2 diabetes mellitus in 2005

For many patients, these symptoms diminish over time as the body adapts to the medication, as noted in the Summaries of Product Characteristics (SmPCs)

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Wegovy and other GLP-1 receptor agonists have been associated with modest increases in resting heart rate (approximately 2-3 beats per minute on average according to the SmPC, though some individuals may experience larger increases)

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