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The FDA's April 30, 2026 proposal would close the last major 503B pathway for these molecules if finalized before the June 29 comment deadline

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10.1016/j.mce.2023.112139 30 GongL.MaiY.WuZ.LuoJ.WenG

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Obesity rates have almost tripled since 1975, which researchers say is due to a combination of factors, including: Increased access to energy-dense food coupled with reduced physical activity Sleep deprivation Circadian desynchronization Chronic stress A rise in the use of certain medications known to result in weight gain, including some anti-epileptic and psychotropic drugs Other genetic and environmental factors As a result, prescription drug companies have sought their own way to target the treatment of obesity