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Furthermore, the endogenously produced and secreted pyruvate in TNBC cell lines exhibited the capacity to markedly diminish the sensitivity of recipient cells to glutaminase inhibition through a paracrine mechanism [224]

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A study demonstrated that during the early phases of cisplatin-associated acute kidney injury (AKI), mincle cells were produced mainly in the macrophages of the kidney

Compared with cystine, GSH is highly abundant in the microenvironment of tumours, and supplementation with GSH or its product cysteinylglycine rescues cancer cell growth in cystine-depleted conditions

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Muguerza B, Castilla-Cortzar I, Garca M, Quiroga J, Santidrin S, Prieto J