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For example, CRT and other DAMPs can be used to enhance the efficacy of DC vaccines, or IL-10 signaling can be blocked to reverse the immunosuppressive microenvironment, thereby optimizing the anti-tumor immune response (210)

NAD+ injections are used in integrative and functional medicine settings for a variety of potential benefits, although research is still emerging

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Future clinical development should focus on biomarker-guided patient selection and the development of formulations that ensure consistent bioavailability to maximize therapeutic efficacy

Additionally, perirenal adipose tissue, functioning as an active endocrine organ, secretes adipokines and inflammatory factors that further disrupt bone metabolic balance, promoting the progression of osteoporosis

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