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ABC transporters are largely known to actively prevent accumulation of drugs and other agents in the brain [12, 18, 19]

In a clinical trial of semaglutide injection for weight loss (Wegovy) in patients with T2DM and a BMI of 27 kg/m2 or more, hypoglycemia (defined as a plasma glucose less than 54 mg/dL) was reported in 6.2% of semaglutide-treated patients versus 2.5% of placebo-treated patients

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therefore, a temperature of 60 C was chosen for the synthesis, instead of the physiological temperature (37 C)

This field continues to evolve as researchers look for novel diagnostic and therapeutic applications