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In response, enteroendocrine cells upregulate GLP-1 secretion, and GLP-1 receptor activation has been shown to suppress pro-inflammatory cytokines and macrophage infiltration

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GLP-1 receptor agonists mimic this hormone, increasing insulin secretion, slowing digestion, and reducing hungermaking them effective for both diabetes management and weight loss

This led to intensive research efforts focused on modifying the structure of GLP-1 to enhance its stability and prolong its action in the body

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