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Other contributors include faulty axonal transport, resulting in buildup of neurofilaments and synaptic breakdown (Taylor et al., 2016), and genetic mutationssuch as SOD1 (causing harmful protein accumulation), FUS (interfering with RNA handling), and TBK1 or OPTN (which impair the cell's waste disposal system known as autophagy

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Biochimica et Biophysica Acta (BBA)-Rev Cancer

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doi:10.1021/acs.jpcb.0c06502 [cited 2022 July 6] 20