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Avoid stimulant laxatives (senna, bisacodyl) unless recommended by your provider, as regular use can create dependency and weaken natural bowel contractions over time

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Additionally, angiotensin II contributes to endothelial dysfunction by inducing expression of vascular endothelial growth factor and increasing reactive oxygen species, which reduce the bioavailability of vasodilators (such as nitrous oxide) responsible for maintaining normal glomerular vascular tone [14]

It is important to note that PPA affects multiple systems in a complex manner and the evidence of increased PPA or other short-chain fatty-acids being involved in the pathophysiology of ASD, although compelling, is circumstantial at this stage