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These are single molecules engineered to activate two or more distinct receptor systems simultaneously, such as dual GLP-1R/GIPR agonists (e.g., Tirzepatide) or tri-agonists that also target the glucagon receptor
[DOI] [PubMed] [Google Scholar] 54.Raymond J.L., Morrow K
For instance, in glucose-deficient glioblastoma, heightened SLC7A11 expression leads to the generation of ROS and oxidative stress through the consumption of intracellular NADPH during the conversion of imported L-cystine to L-cysteine ( in vivo , within a tumor microenvironment, where the metabolic reprogramming associated with altered SLC7A11 expression was evident ( in vivo experiments demonstrated that heightened SLC7A11 expression facilitated localized tumor growth while impeding tumor migration
Progress in understanding 2-hydroxyglutaric acidurias
