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Activated Parkin ubiquitinates outer mitochondrial membrane proteins including Mfn1, Mfn2, Miro1, and VDAC1 (Tanaka et al., 2010), followed by PINK1-mediated phosphorylation of these ubiquitinated substrates to amplify polyubiquitin chain signaling (Turco et al., 2021)

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[50] made a biodegradable hydrogel composite scaffold with macromonomer oligo (polyethylene glycol) fumarate (OPF), which simulated the structural layer of the osteochondral unit

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This stability can improve experimental consistency, making it easier to identify meaningful results and reducing variability in data